Unclogging a main drain can be a crucial yet tricky task, and the cost can vary based on location and severity. On average, drain cleaning cost in Florida ranges between $150 to $400. Factors like the complexity of the clog, the tools required, and whether it's an emergency service play a role. To get a clear estimate, it’s wise to contact a local plumber who can assess the situation and provide an accurate quote. Staying informed about the average drain cleaning cost can help you avoid surprises and ensure your drains are back to flowing freely.